Functional Nonequivalence of and Hemes in Human Adult Hemoglobin
نویسندگان
چکیده
منابع مشابه
Functional nonequivalence of and hemes in human adult hemoglobin.
Nuclear magnetic resonance studies of the contact-shifted spectra of heme protons in deoxyhemoglobin A from human adults show conclusively that oxygen binds to the alpha hemes in preference to the beta hemes. The preferential binding is produced in 10% hemoglobin solution at neutral pH by either a 15-fold molar excess of 2,3-diphosphoglycerate or a 5-fold molar excess of inositol hexaphosphate....
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The Problem.-Heme-heme interaction in hemoglobin may be defined briefly as the dependence of the ligand-binding properties of a particular subunit heme upon the state of liganding of other subunit hemes in the same tetramer. The existence of such dependence is clearly demonstrated by a comparison of the equilibrium ligand-binding properties of the isolated a and , subunits with that of hemoglob...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1972
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.69.7.1707